The Chemokine System in Experimental and Clinical Hematology - ReadingSample

Chemokines induce cell migration through the activation of a distinct family of structurally related heterotrimeric G protein-coupled receptors (GPCR). Over the last few years, several receptors in this family that recognize chemokines but do not induce cell migration have been identified. These “atypical” chemokine receptors are unable to activate transduction events that lead directly to cell migration, but appear nonetheless to play a nonredundant role in the control of leukocyte recruitment at inflammatory sites and in tumors by shaping the R. Bonecchi, B. Savino, E.M. Borroni, A. Mantovani (*), and M. Locati Department of Translational Medicine, University of Milan, 20089 Rozzano, Milan, Italy IRCCS Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Milan, Italy e-mail: [email protected] Ø. Bruserud (ed.), The Chemokine System in Experimental and Clinical Hematology, Current Topics in Microbiology and Immunology 341, DOI 10.1007/82_2010_19 # Springer‐Verlag Berlin Heidelberg 2010, published online: 1 April 2010 15 chemoattractant gradient, either by removing, transporting, or concentrating their